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KMID : 0379520110270020095
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한국독성학회지
2011 Volume.27 No. 2 p.95 ~ p.102
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Effect of DHU001, a Polyherbal Formula on Formalin-induced Paw Chronic Inflammation of Mice
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Cho Yoon-Hee
Chung In-Kwon
Cheon Woo-Hyun
Lee Hyeung-Sik
Ku Sae-Kwang
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Abstract
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The effect of DHU001, a mixed herbal formula consisted of 7 types aqueous extracts for various respiratory disorders were evaluated on the formalin-induced paw chronic inflammation in mice after oral administration. Mice were subaponeurotically injected in the left hind paw with 0.02 ㎖ of 3.75% formalin, then subjected to 500, 250 and 125 ㎎/㎏ of DHU001 oral administration, once a day for 10 days during which then the hind-paw thickness and volume were measured daily. The paw wet-weight, histological profiles, histomorphometrical analyses and paw tumor necrosis factor (TNF)-α contents were conducted at termination. After two formalin treatments, a marked increase in the paw thickness and volume was detected in the formalin-injected control as compared with that in the intact control, plus at the time of sacrifice the paw wet-weights, paw TNF-α contents were also dramatically increased with severe chronic inflammation signs at histopathological observations. However, these formalin-induced chronic inflammatory changes were dramatically decreased by treatment of dexamethasone and all three different dosages of DHU001. DHU001 has favorable effects on formalin-induced chronic inflammation mediated by TNF-α suppression, and DHU001 may represent an alternative approach for the treatment of chronic inflammatory diseases.
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KEYWORD
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DHU001, Polyherbal Formula, Chronic Inflammation, Mouse, Tumor Necrosis Factor
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